A positive allosteric modulator of α6β3γ2 subunit-containing GABAA receptors
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Product Categories

Product Type

Small Molecule Modulators
Ion Channel Modulators

Research Area

Neuroscience

LAU-159

Item No. 26336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-chloro-2,5-dihydro-2-(3-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one
CAS Number
2055050-87-6
Molecular Formula
C17H12ClN3O2
Formula Weight
325.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
220, 290 nm
SMILES
ClC1=CC2=C(C=C1)NC=C3C2=NN(C4=CC=CC(OC)=C4)C3=O
InChi Code
InChI=1S/C17H12ClN3O2/c1-23-12-4-2-3-11(8-12)21-17(22)14-9-19-15-6-5-10(18)7-13(15)16(14)20-21/h2-9,19H,1H3
InChi Key
WQYIIWQWPXNTAK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $29

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    5 mg

    $135

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    10 mg

    $253

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    25 mg

    $597

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    Product Description

    LAU-159 is a positive allosteric modulator (PAM) of α6β3γ2 subunit-containing GABAA receptors.1 It selectively increases GABA-induced currents in X. laevis oocytes expressing α6β3γ2 over α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, and α5β3γ2 subunit-containing receptors at 10 μM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Treven, M., Siebert, D.C.B., Holzinger, R., et al. Towards functional selectivity for α6β3γ2 GABAA receptors: A series of novel pyrazoloquinolinones. Br. J. Pharmacol. 175(3), 419-428 (2019).