A PRDM9 inhibitor
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MRK-740

Item No. 26387

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methyl-4-pyridinyl)-1,4,9-triazaspiro[5.5]undecane
CAS Number
2387510-80-5
Molecular Formula
C25H32N6O3
Formula Weight
464.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=CC(N2CCC3(CN(C4=NC(C5=CC(OC)=CC(OC)=C5)=NO4)CCN3C)CC2)=CC=N1
InChi Code
InChI=1S/C25H32N6O3/c1-18-13-20(5-8-26-18)30-9-6-25(7-10-30)17-31(12-11-29(25)2)24-27-23(28-34-24)19-14-21(32-3)16-22(15-19)33-4/h5,8,13-16H,6-7,9-12,17H2,1-4H3
InChi Key
NZYTZRHHBAJPKN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $132

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    10 mg

    $229

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    Product Description

    MRK-740 is an inhibitor of the lysine methyltransferase PR/SET domain 9 (PRDM9; IC50 = 80 nM).1 It inhibits PRDM9-dependent trimethylation of ectopic histone H3K4 (IC50 = 0.8 µM) and endogenous H3K4 in HEK293 cells in a concentration-dependent manner. MRK-740 induces meiotic defects in mouse spermatocytes. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Allali-Hassani, A., Szewczyk, M.M., Ivanochko, D., et al. Discovery of a chemical probe for PRDM9. Nat. Commun. 10(1), 5759 (2019).