A prodrug form of ETC-1002-CoA
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ETC-1002

Item No. 26409

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-hydroxy-2,2,14,14-tetramethyl-pentadecanedioic acid
CAS Number
738606-46-7
Synonyms
  • Bempedoic Acid
  • ESP-55016
Molecular Formula
C19H36O5
Formula Weight
344.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 2 mg/ml
SMILES
OC(C(C)(C)CCCCCC(O)CCCCCC(C)(C)C(O)=O)=O
InChi Code
InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChi Key
HYHMLYSLQUKXKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $55

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    25 mg

    $86

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    50 mg

    $135

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    Product Description

    ETC-1002 is a prodrug form of ETC-1002-CoA.1 ETC-1002 is conjugated to coenzyme A (CoA) by very long-chain acyl-CoA synthetase-1 (ACSVL1) to form ETC-1002-CoA, which inhibits ATP citrate lyase (Ki = 2 μM) and activates AMP-activated protein kinase (AMPK). ETC-1002 suppresses total lipid synthesis in wild-type and AMPKβ1 knockout primary murine hepatocytes. In vivo, ETC-1002 (30 mg/kg) prevents increases in hepatic cholesterol and reduces the size of aortic atherosclerotic lesions induced by a high-fat high-cholesterol diet in Apoe-/-/Ampkβ1-/- (DKO) mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pinkosky, S.L., Newton, R.S., Day, E.A., et al. Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis. Nat. Commun. 7:13457, (2016).