A GABAA receptor ligand
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U-93631

Item No. 26417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid, 1,1-dimethylethyl ester
CAS Number
152273-12-6
Molecular Formula
C17H21N3O2
Formula Weight
299.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
222, 325 nm
SMILES
CC1(C)C2=C(C(OC(C)(C)C)=O)N=CN2C3=C(C=CC=C3)N1
InChi Code
InChI=1S/C17H21N3O2/c1-16(2,3)22-15(21)13-14-17(4,5)19-11-8-6-7-9-12(11)20(14)10-18-13/h6-10,19H,1-5H3
InChi Key
NXBSEJKZKXIYMD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $141

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    50 mg

    $268

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    100 mg

    $478

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    Product Description

    U-93631 is a GABAA receptor ligand.1 It accelerates decay of GABA-induced currents in HEK293 cells expressing rat α1β2, β2γ2, and α1γ2 subunit-containing GABAA receptors when used at a concentration of 5 μM. U-93631 inhibits radioligand binding to the picrotoxin site on α1β2γ2 subunit-containing GABAA receptors.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dillon, G.H., Im, H.K., Hamilton, B.J., et al. U-93631 causes rapid decay of γ-aminobutyric acid-induced chloride currents in recombinant rat γ-aminobutyric acid type A receptors. Mol. Pharmacol. 44(4), 860-865 (1993).

    2. Dillon, G.H., Im, W.B., Pregenzer, J.F., et al. [4-Dimethyl-3-t-butylcarboxyl-4,5-dihydro (1,5-a) quinoxaline] is a novel ligand to the picrotoxin site on GABAA receptors, and decreases single-channel open probability. J. Pharmacol. Exp. Ther. 272(2), 597-603 (1995).