A fungal metabolite
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(+)-Geodin

Item No. 26421

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1'R)-5,7-dichloro-4-hydroxy-6'-methoxy-6-methyl-3,4'-dioxo-spiro[benzofuran-2(3H),1'-[2,5]cyclohexadiene]-2'-carboxylic acid, methyl ester
CAS Number
427-63-4
Molecular Formula
C17H12Cl2O7
Formula Weight
399.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleDMSO: solubleEthyl Acetate: solubleMethanol: soluble
SMILES
O=C1C2=C(O)C(Cl)=C(C)C(Cl)=C2O[C@]13C(OC)=CC(C=C3C(OC)=O)=O
InChi Code
InChI=1S/C17H12Cl2O7/c1-6-11(18)13(21)10-14(12(6)19)26-17(15(10)22)8(16(23)25-3)4-7(20)5-9(17)24-2/h4-5,21H,1-3H3/t17-/m1/s1
InChi Key
LUBKKVGXMXTXOZ-QGZVFWFLSA-N
Origin
Fungus/Penicillium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    (+)-Geodin is a fungal metabolite.1,2 It increases the fibrinolytic activity of bovine aortic endothelial cells (BAECs) when used at concentrations ranging from 50 to 150 µM.1 (+)-Geodin (1-100 µg/ml) also increases 2-deoxyglucose uptake by rat adipocytes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shinohara, C., Chikanishi, T., Nakashima, S., et al. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B. J. Antibiot. (Tokyo) 53(3), 262-268 (2000).

    2. Sato, S., Okusa, N., Ogawa, A., et al. Identification and preliminary SAR studies of (+)-geodin as a glucose uptake stimulator for rat adipocytes. J. Antibiot. (Tokyo) 58(9), 583-589 (2005).