An antiprion agent
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Chloroguanabenz (acetate)

Item No. 26423

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(E)-2-(2,3,6-trichlorobenzylidene)hydrazine-1-carboximidamide, monoacetate
Molecular Formula
C8H7Cl3N4 • C2H4O2
Formula Weight
325.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1Cl.OC(C)=O
InChi Code
InChI=1S/C8H7Cl3N4.C2H4O2/c9-5-1-2-6(10)7(11)4(5)3-14-15-8(12)13;1-2(3)4/h1-3H,(H4,12,13,15);1H3,(H,3,4)/b14-3+;
InChi Key
GKLCICRSHLCLBI-UFJIHACCSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $233

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    Product Description

    Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz (Item No. 10851).1 It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tribouillard-Tanvier, D., Béringue, V., Desban, N., et al. Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions. PLoS One 3(4), e1981 (2008).

    2. Bertolotti, A., and Blondel, M. Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases. (2011).