A synthetic progestin
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Segesterone Acetate

Item No. 26441

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
17-(acetyloxy)-16-methylene-19-norpregn-4-ene-3,20-dione
CAS Number
7759-35-5
Synonyms
  • ST-1435
Molecular Formula
C23H30O4
Formula Weight
370.5
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
C[C@@]12[C@](CC([C@]2(OC(C)=O)C(C)=O)=C)([H])[C@]3([H])CCC4=CC(CC[C@]4([H])[C@@]3([H])CC1)=O
InChi Code
InChI=1S/C23H30O4/c1-13-11-21-20-7-5-16-12-17(26)6-8-18(16)19(20)9-10-22(21,4)23(13,14(2)24)27-15(3)25/h12,18-21H,1,5-11H2,2-4H3/t18-,19+,20+,21-,22-,23-/m0/s1
InChi Key
CKFBRGLGTWAVLG-GOMYTPFNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    Product Description

    Segesterone acetate is a synthetic progestin that binds to the progesterone receptor (EC50 = 50.3 nM).1 It increases uterine weight in rabbits (ED50 = ~1 µg), maintains pregnancy in 40-50% of rats when administered at doses ranging from 0.03 to 0.1 mg per day, and completely inhibits spontaneous ovulation in rats at a dose of 10 µg per day. It also binds to the glucocorticoid receptor (EC50 = 56 nM) but does not have in vivo glucocorticoid activity. Segesterone acetate (8 µg, i.c.v., via osmotic minipump over four weeks) increases cell proliferation in the adult female mouse brain, increasing the production of new neurons and oligodendrocytes.2 Sustained-release formulations containing segesterone have been used as contraceptives.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, N., Koide, S.S., Tsong, Y.-Y., et al. Nestorone®: A progestin with a unique pharmacological profile. Steroids 65(10-11), 629-636 (2000).

    2. Chen, S., Kumar, N., Mao, Z., et al. Therapeutic progestin segesterone acetate promotes neurogenesis: Implications for sustaining regeneration in female brain. Menopause 25(10), 1138-1151 (2018).