A bacterial metabolite
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Pyrocoll

Item No. 26464

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10-dione
CAS Number
484-73-1
Molecular Formula
C10H6N2O2
Formula Weight
186.2
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(N1C2=CC=C1)C3=CC=CN3C2=O
InChi Code
InChI=1S/C10H6N2O2/c13-9-7-3-1-5-11(7)10(14)8-4-2-6-12(8)9/h1-6H
InChi Key
USCZWOZHDDOBHQ-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $334

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    5 mg

    $1,247

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    Cayman Chemical
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    Product Description

    Pyrocoll is a bacterial metabolite originally isolated from Streptomyces.1 It inhibits the growth of A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis bacteria (MICs = 10, 1, 10, 3, and 10 μg/ml, respectively) and HMO2, HepG2, and MCF-7 cancer cells (GI50s = 0.28, 0.42, and 2.2 μg/ml, respectively) in vitro. Pyrocoll is also active against P. falciparum and T. rhodesiense (IC50s = 1.19 and 1.97 μg/ml, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dietera, A., Hamm, A., Fiedler, H.P., et al. Pyrocoll, an antibiotic, antiparasitic and antitumor compound produced by a novel alkaliphilic Streptomyces strain. J. Antibiot. (Tokyo) 56(7), 639-646 (2003).