A metabolite of 11-deoxycortisol
Related Products
Parent Compound(s)
2077511-deoxy Cortisol
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Tetrahydro-11-deoxy Cortisol

Item No. 26501

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5β-3α,17,21-trihydroxy-pregnan-20-one
CAS Number
68-60-0
Synonyms
  • NSC 53901
  • 5β-Pregnane-3α,17α,21-triol-20-one
  • Tetrahydrodeoxycortisol
  • THS
Molecular Formula
C21H34O4
Formula Weight
350.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.2 mg/ml
SMILES
O[C@@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)([H])C1
InChi Code
InChI=1S/C21H34O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h13-17,22-23,25H,3-12H2,1-2H3/t13-,14-,15-,16+,17+,19+,20+,21+/m1/s1
InChi Key
UPTAPIKFKZGAGM-FAIYVORSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $82

    Add

    50 mg

    $303

    Add

    100 mg

    $564

    Add

    250 mg

    $803

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol.1,2 Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Keavney, B., Mayosi, B., Gaukrodger, N., et al. Genetic variation at the locus encompassing 11-β hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. J. Clin. Endocrinol. Metab. 90(2), 1072-1077 (2005).

    2. Nguyen, H.-H., Eiden-Plach, A., Hannemann, F., et al. Phenotypic, metabolic, and molecular genetic characterization of six patients with congenital adrenal hyperplasia caused by novel mutations in the CYP11B1 gene. J. Steroid Biochem. Mol. Biol. 155(Pt A), 126-134 (2016).

    3. Arlt, W., Biehl, M., Taylor, A.E., et al. Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. J. Clin. Endocrinol. Metab. 96(12), 3775-3784 (2011).

    4. Velikanova, L.I., Shafigullina, Z.R., Lisitsin, A.A., et al. Different types of urinary steroid profiling obtained by high-performance liquid chromatography and gas chromatography-mass spectrometry in patients with adrenocortical carcinoma. Horm. Cancer 7(5-6), 327-335 (2016).