A thrombopoietin receptor agonist
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Avatrombopag

Item No. 26535

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-4-piperidinecarboxylic acid
CAS Number
570406-98-3
Synonyms
  • AKR 501
  • AS 1670542
  • YM477
Molecular Formula
C29H34Cl2N6O3S2
Formula Weight
649.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
λmax
325 nm
SMILES
ClC1=CC(C(NC2=NC(C3=CC(Cl)=CS3)=C(N4CCN(C5CCCCC5)CC4)S2)=O)=CN=C1N6CCC(C(O)=O)CC6
InChi Code
InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38)
InChi Key
OFZJKCQENFPZBH-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $183

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    25 mg

    $328

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    50 mg

    $502

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    Product Description

    Avatrombopag is an agonist of the thrombopoietin receptor.1 It induces proliferation of Ba/F3 cells expressing the thrombopoietin receptor (EC50 = 3.3 nM) and induces differentiation of hematopoietic progenitor cells into megakaryotes. Avatrombopag is species-specific, inducing STAT5 phosphorylation in human and chimpanzee blood platelets, but not in olive baboon, rhesus monkey, rat, hamster, or several other species blood platelets. It increases the number of human platelets in NOD/SCID mice transplanted with CD34+ human fetal liver cells when administered at doses of 1 and 3 mg/kg. Formulations containing avatrombopag have been used in the treatment of thrombocytopenia in adults.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fukushima-Shintani, M., Suzuki, K., Iwatsuki, Y., et al. AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur. J. Haematol. 82(4), 247-254 (2009).