A PAD3 inhibitor
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CAY10727

Item No. 26543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[3-[1-[(2'-chloro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxo-4-imidazolidinyl]propyl]-ethanimidamide
CAS Number
1671088-84-8
Molecular Formula
C21H22Cl2N4O2
Formula Weight
433.3
Purity
≥90%
Formulation
A 500 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 10 mg/ml
SMILES
ClC1=CC=CC=C1C2=CC=CC(CN3C(NC(CCCNC(CCl)=N)C3=O)=O)=C2
InChi Code
InChI=1S/C21H22Cl2N4O2/c22-12-19(24)25-10-4-9-18-20(28)27(21(29)26-18)13-14-5-3-6-15(11-14)16-7-1-2-8-17(16)23/h1-3,5-8,11,18H,4,9-10,12-13H2,(H2,24,25)(H,26,29)
InChi Key
WBAMTPWAOJULCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $134

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    250 µg

    $283

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    500 µg

    $530

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    1 mg

    $926

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    Product Description

    CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; kinact/KI = 15,600 M-1min-1).1 It is selective for PAD3 over PAD1, -2, and -4 (kinact/KIs = 360, 1,110, and 1,460 M-1min-1, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jamali, H., Khan, H.A., Stringer, J.R., et al. Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J. Am. Chem. Soc. 137(10), 3616-3621 (2015).