An internal standard for the quantification of propionyl-L-carnitine
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Unlabeled Version(s)
9001873Propionyl-L-carnitine (chloride)
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Propionyl-L-carnitine-d3 (chloride)

Item No. 26579

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(1-oxopropoxy)-1-propanaminium, monochloride
CAS Number
1334532-19-2
Synonyms
  • C3:0 Carnitine-d3
  • CAR 3:0-d3
  • L-Carnitine propionyl ester-d3
  • Levocarnitine propionate-d3
  • L-Propionylcarnitine-d3
Molecular Formula
C10H17D3NO4 • Cl
Formula Weight
256.7
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[N+](C)(C([2H])([2H])[2H])C[C@@H](CC(O)=O)OC(CC)=O.[Cl-]
InChi Code
InChI=1S/C10H19NO4.ClH/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4;/h8H,5-7H2,1-4H3;1H/t8-;/m1./s1/i2D3;
InChi Key
KTFMPDDJYRFWQE-WVKKGGDISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Propionyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of propionyl-L-carnitine (Item No. 9001873) by GC- or LC-MS. Propionyl-L-carnitine is a naturally occurring carnitine derivative formed by carnitine acetyltransferase during β-oxidation of uneven chain fatty acids.1 Propionyl-L-carnitine increases the basal release of prostaglandin E2 (PGE2; Item No. 14010) and 6-keto Prostaglandin F1α (Item No. 15210) in carrageenan-stimulated isolated rat peritoneal cells contaminated with neutrophils and increases the basal release of thromboxane B2 (TXB2; Item No. 19030) in non-contaminated cells.1 It reduces the production of reactive oxygen species (ROS) and decreases the expression of NADPH oxidase 2 (NOX2), NOX4, and ICAM-1 in human umbilical vein endothelial cells (HUVECs). It also increases the rate of revascularization and the hind limb vascular area in a rabbit model of hind limb ischemia when administered at a dose of 10 mg per animal.2 Propionyl-L-carnitine reduces mitochondrial dysfunction induced by ischemia, preventing mitochondrial calcium overload, and depletion of ATP tissue stores in a rabbit model of ischemia.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garrelds, I.M., Elliott, G.R., Pruimboom, W.M., et al. Effects of carnitine and its congeners on eicosanoid discharge from rat cells: Implications for release of TNFα. Mediators Inflamm. 2(7), S57-S62 (1993).

    2. Stasi, M.A., Scioli, M.G., Arcuri, G., et al. Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production. Arterioscler. Thromb. Vasc. Biol. 30(3), 426-435 (2010).

    3. Ferrari, R., Ceconi, C., Cargnoni, A., et al. The effect of propionyl-L-carnitine on the ischemic and reperfused intact myocardium and on their derived mitochondria. Cardiovasc. Drugs Ther. 5 (Suppl 1), 57-65 (1991).