An internal standard for the quantification of bromfenac
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Unlabeled Version(s)
23763Bromfenac (sodium salt)
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Bromfenac-d4 (sodium salt)

Item No. 26598

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-3-(4-bromobenzoyl-2,3,5,6-d4)-benzeneacetic acid, monosodium salt
CAS Number
2749400-35-7
Molecular Formula
C15H7BrD4NO3 • Na
Formula Weight
360.2
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 5 mMWater: 100 mM
SMILES
BrC1=C([2H])C([2H])=C(C(C2=CC=CC(CC([O-])=O)=C2N)=O)C([2H])=C1[2H].[Na+]
InChi Code
InChI=1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;/h1-7H,8,17H2,(H,18,19);/q;+1/p-1/i4D,5D,6D,7D;
InChi Key
HZFGMQJYAFHESD-OAIJHCBKSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $303

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    1 mg

    $574

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    Product Description

    Bromfenac-d4 is intended for use as an internal standard for the quantification of bromfenac (Item No. 23763) by GC- or LC-MS. Bromfenac is an inhibitor of cyclooxygenase 2 (COX-2; IC50 = 6.6 nM) that is selective over COX-1 (IC50 = 210 nM).1 It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in a rabbit model of LPS-induced eye inflammation. Bromfenac also decreases inflammation following cataract removal in dogs when administered as a 0.9% topical solution on a tapering schedule for 24 weeks.2 Formulations containing bromfenac have been used in the treatment of postoperative inflammation following cataract surgery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Waterbury, L.D., Silliman, D., and Jolas, T. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr. Med. Res. Opin. 22(6), 1133-1140 (2006).

    2. Brookshire, H.L., English, R.V., Nadelstein, B., et al. Efficacy of COX-2 inhibitors in controlling inflammation and capsular opacification after phacoemulsification cataract removal. Vet. Ophthalmol. 18(3), 175-185 (2015).