A COX inhibitor
Related Products
Labeled Version(s)
35056Flunixin-d3
Metabolite(s)
339305-hydroxy Flunixin
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Flunixin (meglumine)

Item No. 26644

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-deoxy-1-(methylamino)-D-glucitol, 2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate
CAS Number
42461-84-7
Synonyms
  • NIH 10250
Molecular Formula
C14H11F3N2O2 • C7H17NO5
Formula Weight
491.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 0.25 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
279 nm
SMILES
CC1=C(NC2=NC=CC=C2C(O)=O)C=CC=C1C(F)(F)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
InChi Code
InChI=1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
InChi Key
MGCCHNLNRBULBU-WZTVWXICSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $49

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    100 mg

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    250 mg

    $202

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    500 mg

    $376

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    Product Description

    Flunixin is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 (IC50s = 3.24 and 0.55 µM, respectively).1 It inhibits carrageenan-induced prostaglandin E2 (PGE2; Item No. 14010) and thromboxane B2 (TXB2; Item No. 19030) production in sheep exudate and serum, respectively, when administered at a dose of 1.1 mg/kg.2 Flunixin (1.1 mg/I/kg) has anti-inflammatory, analgesic, and antipyretic activity in horses.3 Formulations containing flunixin have been used in the veterinary treatment of pain and fever in livestock.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bryant, C.E., Farnfield, B.A., and Janicke, H.J. Evaluation of the ability of carprofen and flunixin meglumine to inhibit activation of nuclear factor kappa B. Am. J. Vet. Res. 64(2), 211-215 (2003).

    2. Cheng, Z., Nolan, A.M., and McKellar, Q.A. Measurement of cyclooxygenase inhibition in vivo: A study of two non-steroidal anti-inflammatory drugs in sheep. Inflammation 22(4), 353-366 (1998).

    3. Houdeshell, J.W., and Hennessey, P.W. A new nonsteroidal, anti-inflammatory analgesic for horses. J. Equine Vet Sci. 1(2), 57-63 (1977).