An aminoglycoside antibiotic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Netilimicin (sulfate)

Item No. 26666

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N1-ethyl-D-streptamine, sulfate (2:5)
CAS Number
56391-57-2
Synonyms
  • Netillin
  • Netilyn
Molecular Formula
C21H41N5O7 • 2.5H2SO4
Formula Weight
720.8
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](NCC)[C@H](O[C@]3([H])[C@H](O)[C@@H](NC)[C@@](C)(O)CO3)[C@H]2O)([H])OC(CN)=CC1.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O
InChi Code
InChI=1S/C21H41N5O7.3H2O4S/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20;3*1-5(2,3)4/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3;3*(H2,1,2,3,4)/t11-,12+,13-,14+,15-,16-,17+,18-,19-,20-,21+;;;/m1.../s1
InChi Key
MADCIBJSLWDZDF-JPAWNEMXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    10 mg

    $107

    Add

    25 mg

    $213

    Add

    50 mg

    $371

    Add

    100 mg

    $583

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Netilimicin is an aminoglycoside antibiotic.1 It is active against S. aureus, N. gonorrhoeae, E. coli, P. mirabilis, and P. aeruginosa (MICs = 0.4, 3.1, 0.8, 1.6, and 0.4 µg/ml, respectively) as well as Enterococci, Enterobacter, Citrobacter, and Klebsiella species (MICs = 3.1, 0.4, 0.8, and ≤0.2 µg/ml, respectively). Netilimicin induces nephrotoxicity in rats when administered at doses ranging from 50 to 150 mg/kg.2 It also induces neuromuscular block, decreasing twitch tension in isolated diaphragm and soleus muscles in rabbits (ED50s = 18.5 and 62.2 mg/kg, respectively).3 Formulations containing netilimicin were previously used in the intravenous treatment of severe bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sanders, C.C., Sanders W.E., J., and Goering, R.V. In vitro studies with Sch 21420 and Sch 22591: Activity in comparison with six other aminoglycosides and synergy with penicillin against enterococci. Antimicrob. Agents Chemother. 14(2), 178-184 (1978).

    2. Bowman, R.L., Silverblatt, F.J., and Kaloyanides, G.J. Comparison of the nephrotoxicity of netilmicin and gentamicin in rats. Antimicrob. Agents Chemother. 12(4), 474-478 (1977).

    3. Liu, M., Kato, M., and Hashimoto, Y. Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit. Pharmacology 63(3), 142-146 (2001).