A metabolite of posaconazole
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Parent Compound(s)
14737Posaconazole
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Posaconazole D-Glucuronide

Item No. 26684

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,3S,4S,5R,6R)-6-(1-(((2R,4R)-2-(2,4-difluorophenyl)-4-((4-(4-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl)phenyl)piperazin-1-yl)phenoxy)methyl)tetrahydrofuran-2-yl)methyl)-1H-1,2,4-triazol-4-ium-4-yl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate
Synonyms
  • Posaconazole N-β-D-Glucuronide
Molecular Formula
C43H50F2N8O10
Formula Weight
876.9
Purity
≥80%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: slightly soluble
SMILES
O=C1N([C@H]([C@@H](O)C)CC)N=CN1C(C=C2)=CC=C2N3CCN(C4=CC=C(OC[C@@H]5CO[C@@](CN6C=[N+]([C@@]7([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C([O-])=O)O7)C=N6)(C8=CC=C(F)C=C8F)C5)C=C4)CC3
InChi Code
InChI=1S/C43H50F2N8O10/c1-3-35(26(2)54)53-42(60)52(24-47-53)31-7-5-29(6-8-31)48-14-16-49(17-15-48)30-9-11-32(12-10-30)61-20-27-19-43(62-21-27,33-13-4-28(44)18-34(33)45)22-51-25-50(23-46-51)40-38(57)36(55)37(56)39(63-40)41(58)59/h4-13,18,23-27,35-40,54-57H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,36-,37-,38+,39-,40+,43-/m0/s1
InChi Key
OMNLHWYFOPMQCO-KYMKPJGSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    Posaconazole D-glucuronide is a metabolite of the antifungal agent posaconazole (Item No. 14737).1 It is formed via glucuronidation by the UDP-glucuronosyltransferase (UGT) isoform UGT1A4.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ghosal, A., Hapangama, N., Yuan, Y., et al. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of posaconazole (Noxafil). Drug Metab. Dispos. 32(2), 32(32) (2004).