A lignan
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Schisantherin B

Item No. 26716

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2Z)-2-methyl-2-butenoic acid, (5S,6S,7S,13aS)-5,6,7,8-tetrahydro-6-hydroxy-1,2,3,13-tetramethoxy-6,7-dimethylbenzo[3,4]cycloocta[1,2-f][1,3]benzodioxol-5-yl ester
CAS Number
58546-55-7
Synonyms
  • Gomisin B
  • Schizantherin B
  • Wuweizi ester B
Molecular Formula
C28H34O9
Formula Weight
514.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 5 mg/mlEthanol: 2 mg/ml
λmax
219 nm
SMILES
COC1=C(OCO2)C2=CC3=C1C4=C(C=C(OC)C(OC)=C4OC)[C@H](OC(/C(C)=C\C)=O)[C@](O)(C)[C@@H](C)C3
InChi Code
InChI=1S/C28H34O9/c1-9-14(2)27(29)37-26-17-12-18(31-5)22(32-6)25(34-8)21(17)20-16(10-15(3)28(26,4)30)11-19-23(24(20)33-7)36-13-35-19/h9,11-12,15,26,30H,10,13H2,1-8H3/b14-9-/t15-,26-,28-/m0/s1
InChi Key
BKGUPIVDQHHVMV-RZGKOBFOSA-N
Origin
Plant/ Schisandra chinensis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $127

    Add

    25 mg

    $297

    Add

    50 mg

    $493

    Add
    Product Description

    Schisantherin B (STB) is a lignan originally isolated from S. sphenanthera fruit.1 It inhibits formation of advanced glycation end products (AGEs) in vitro.2 STB (0.1 mg/kg) decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer's disease induced by amyloid-β (1-42) (Item No. 20574).3 It increases glial expression of glutamate transporter 1 (GLP-1) and decreases immobility time in the forced swim test (FST) in mice, indicating antidepressant-like activity.4 STB also increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, C.S., Fang, S.D., Huang, M.F., et al. Studies on the active principles of Schisandra sphenanthera Rehd. et Wils. The structures of schisantherin A, B, C, D, E, and the related compounds. Sci. Sin. 21(4), 483-502 (1978).

    2. Poornima, B., Kumar, D.A., Siva, B., et al. Advanced glycation end-products inhibitors isolated from Schisandra grandiflora. Nat. Prod. Res. 30(4), 493-496 (2016).

    3. Xu, M., Dong, Y., Wan, S., et al. Schisantherin B ameliorates Aβ1-42-induced cognitive decline via restoration of GLT-1 in a mouse model of Alzheimer’s disease. Physiol. Behav. 167, 265-273 (2016).

    4. Xu, M., Xiao, F., Wang, M., et al. Schisantherin B improves the pathological manifestations of mice caused by behavior desperation in different ages-depression with cognitive impairment. Biomol. Ther. (Seoul) 27(2), 160-167 (2019).