A selective COX-1 inhibitor
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TFAP

Item No. 26745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)-benzamide
CAS Number
1011244-68-0
Molecular Formula
C13H10F3N3O
Formula Weight
281.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 10mg/mLEthanol: 10mg/mLEthanol:PBS (pH 7.2) (1:4): 0.2mg/mL
λmax
223, 317 nm
SMILES
O=C(NC1=CC=C(N)C=N1)C2=CC=C(C(F)(F)F)C=C2
InChi Code
InChI=1S/C13H10F3N3O/c14-13(15,16)9-3-1-8(2-4-9)12(20)19-11-6-5-10(17)7-18-11/h1-7H,17H2,(H,18,19,20)
InChi Key
BTCFFMPDIBWZLF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $219

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    25 mg

    $502

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    Product Description

    TFAP is an inhibitor of COX-1 (IC50 = 0.8 μM).1 It is selective for COX-1 over COX-2 (IC50 = 210 μM). TFAP (10 and 30 mg/kg) reduces acetic acid-induced writhing in mice and has analgesic activity in the formalin test in rats when administered at a dose of 30 mg/kg. It does not induce gastric damage in rats when administered at doses up to 300 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kakuta, H., Zheng, X., Oda, H., et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. Design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J. Med. Chem. 51(8), 2400-2411 (2008).