An internal standard for the quantification of cystamine
Related Products
Unlabeled Version(s)
14882Cystamine (hydrochloride)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cystamine-d8 (hydrochloride)

Item No. 26775

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2'-disulfanediylbis(ethan-1,1,2,2-d4-1-amine), dihydrochloride
CAS Number
2712126-51-5
Molecular Formula
C4H4D8N2S2 • 2HCl
Formula Weight
233.3
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
NC([2H])([2H])C([2H])([2H])SSC([2H])([2H])C([2H])([2H])N.Cl.Cl
InChi Code
InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H/i1D2,2D2,3D2,4D2;;
InChi Key
YUFRRMZSSPQMOS-VHGLFXLXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $41

    Add

    1 mg

    $69

    Add

    5 mg

    $255

    Add

    10 mg

    $389

    Add
    Product Description

    Cystamine-d8 (hydrochloride) is intended for use as an internal standard for the quantification of cystamine (Item No. 14882) by GC- or LC-MS. Cystamine is an organic disulfide that inhibits tissue transglutaminase (TGM2) with an IC50 value of approximately 2.5 mM.1 It is orally available and is neuroprotective in mouse models of Huntington’s disease.2,3 Cystamine also inhibits caspase-3, increases intracellular glutathione, and reduces inflammation in a rat model of inflammatory bowel disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smethurst, P.A., and Griffin, M. Measurement of tissue transglutaminase activity in a permeabilized cell system: Its regulation by Ca2+ and nucleotides. Biochem. J. 313(pt 3), 803-808 (1996).

    2. Dedeoglou, A., Kubilus, J.K., Jeitner, T.M., et al. Therapeutic effects of cystamine in a murine model of Huntington’s disease. J. Neurosci. 22(20), 8942-8950 (2002).

    3. Borrell-Pagès, M., Canals, K.P., Cordelièrs, F.P., et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J. Clin. Invest. 116(5), 1410-1424 (2006).

    4. Elli, L., Ciulla, M.M., Busca, G., et al. Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease. Lab. Invest. 91(3), 452-461 (2011).