An intermediate in the biosynthesis of glycine
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Sarcosine

Item No. 26799

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-glycine
CAS Number
107-97-1
Molecular Formula
C3H7NO2
Formula Weight
89.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
CNCC(O)=O
InChi Code
InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
InChi Key
FSYKKLYZXJSNPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

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    Cayman Chemical
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    Product Description

    Sarcosine is an intermediate in the biosynthesis of glycine from choline.1 It is a selective inhibitor of glycine transporter 1 (GlyT1) with IC50 values of 91 and greater than 1,000 µM for GlyT1 and GlyT2, respectively, in HEK293 cells expressing the human transporters.2 Sarcosine levels are increased in prostate cancer cell lines with an invasive phenotype compared with non-invasive cell lines.3 Sarcosine increases in a progressive fashion in prostate cancer with 0, 42, and 79% of benign, localized, and metastatic prostate tissue samples containing increased levels of sarcosine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, W., Wu, Z., Dai, Z., et al. Glycine metabolism in animals and humans: Implications for nutrition and health. Amino Acids 45(3), 463-477 (2013).

    2. Herdon, H.J., Godfrey, F.M., Brown, A.M., et al. Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes. Neuropharmacology 41(1), 88-96 (2001).

    3. Sreekumar, A., Poisson, L.M., Rajendiran, T.M., et al. Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457(7231), 910-914 (2009).