An inhibitor of VMAT2
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Metabolite(s)
42116NBI 98782
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Valbenazine

Item No. 26809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valine, (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-yl ester
CAS Number
1025504-45-3
Synonyms
  • NBI-98854
Molecular Formula
C24H38N2O4
Formula Weight
418.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 10 mg/ml
SMILES
COC1=C(OC)C=C(CCN2[C@]3([H])C[C@@H](OC([C@@H](N)C(C)C)=O)[C@H](CC(C)C)C2)C3=C1
InChi Code
InChI=1S/C24H38N2O4/c1-14(2)9-17-13-26-8-7-16-10-21(28-5)22(29-6)11-18(16)19(26)12-20(17)30-24(27)23(25)15(3)4/h10-11,14-15,17,19-20,23H,7-9,12-13,25H2,1-6H3/t17-,19-,20-,23+/m1/s1
InChi Key
GEJDGVNQKABXKG-CFKGEZKQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $65

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    25 mg

    $148

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    50 mg

    $215

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    Product Description

    Valbenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2; Kis = 110 and 150 nM in rat striatum homogenates and human platelets, respectively).1 It is selective for VMAT2 over a panel of 80 receptors, transporters, and ion channels, including the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B and dopamine D1 and D2 receptors. Valbenazine induces ptosis in rats, indicating norepinephrine depletion. Formulations containing valbenazine have been used in the treatment of tardive dyskinesia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grigoriadis, D.E., Smith, E., Hoare, S.R.J., et al. Pharmacologic characterization of valbenazine (NBI-98854) and its metabolites. J. Pharmacol. Exp. Ther. 361(3), 454-461 (2017).