A flavonoid
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Apigenin 7-glucoside

Item No. 26813

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
578-74-5
Synonyms
  • 7-O-β-D-Glucopyranosylapigenin
  • Apigenin-7-O-β-D-glucoside
  • Apigetrin
  • Cosmosiin
  • NSC 407303
Molecular Formula
C21H20O10
Formula Weight
432.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): Partially soluble
λmax
269, 336 nm
SMILES
O[C@H]1[C@H](OC2=CC(O)=C(C(C=C(C3=CC=C(O)C=C3)O4)=O)C4=C2)O[C@H](CO)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C21H20O10/c22-8-16-18(26)19(27)20(28)21(31-16)29-11-5-12(24)17-13(25)7-14(30-15(17)6-11)9-1-3-10(23)4-2-9/h1-7,16,18-24,26-28H,8H2/t16-,18-,19+,20-,21-/m1/s1
InChi Key
KMOUJOKENFFTPU-QNDFHXLGSA-N
Origin
Plant/Sow thistle leaf
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Apigenin 7-glucoside is a flavonoid with anti-inflammatory and anxiolytic activities.1,2 It inhibits LPS-induced nitric oxide production in RAW 264.7 cells when used at concentrations ranging from 0.16 to 10 μM.1 In vivo, apigenin 7-glucoside (10 mg/kg) reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury. It also increases the number of entries and the time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, K.C., Ho, Y.L., Hsieh, W.T., et al. Apigenin-7-glycoside prevents LPS-induced acute lung injury via downregulation of oxidative enzyme expression and protein activation through inhibition of MAPK phosphorylation. Int. J. Mol. Sci. 16(1), 1736-1754 (2015).

    2. Kumar, D., and Bhat, Z.A. Apigenin 7-glucoside from Stachys tibetica Vatke and its anxiolytic effect in rats. Phytomedicine 21(7), 1010-1014 (2014).