A monoacylglycerol
Related Products
Isomer(s)
272822-Stearoyl-rac-glycerol
Labeled Version(s)
289191-Stearoyl-rac-glycerol-d40
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1-Stearoyl-rac-glycerol

Item No. 26827

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
octadecanoic acid, 2,3-dihydroxypropyl ester
CAS Number
123-94-4
Synonyms
  • 18:0-MG
  • MG(18:0/0:0/0:0)
  • 1-Monostearin
  • NSC 3875
Molecular Formula
C21H42O4
Formula Weight
358.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 50 mg/ml
SMILES
O=C(CCCCCCCCCCCCCCCCC)OCC(O)CO
InChi Code
InChI=1S/C21H42O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)25-19-20(23)18-22/h20,22-23H,2-19H2,1H3
InChi Key
VBICKXHEKHSIBG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $63

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    250 mg

    $130

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    500 mg

    $242

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    Product Description

    1-Stearoyl-rac-glycerol is a monoacylglycerol that contains stearic acid (Item No. 10011298) at the sn-1 position. 1-Stearoyl-rac-glycerol levels are decreased in tumor tissue in a mouse model of azoxymethane-induced colorectal carcinogenesis.1 Levels of 1-stearoyl-rac-glycerol are decreased in lung tissue from patients with adenocarcinoma, but are increased in the serum of patients with Buruli ulcer and in the cerebrospinal fluid of patients with the inflammatory demyelinating diseases multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and idiopathic transverse myelitis (ITM).2,3,4 1-Stearoyl-rac-glycerol has been used in the composition of transfersomes for transdermal delivery of doxorubicin (Item No. 15007) in rats, leading to doxorubicin accumulation in lymph nodes, spleen, and heart.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Montrose, D.C., Zhou, X.K., Kopelovich, L., et al. Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer Prev. Res. (Phila.) 5(12), 1358-1367 (2012).

    2. Wikoff, W.R., Grapov, D., Fahrmann, J.F., et al. Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma. Cancer Prev. Res. (Phila.) 8(5), 410-418 (2015).

    3. Niang, F., Sarfo, F.S., Frimpong, M., et al. Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease. Sci. Rep. 5:17693, (2015).

    4. Park, S.J., Jeong, I.H., Kong, B.S., et al. Disease type- and status-specific alteration of CSF metabolome coordinated with clinical parameters in inflammatory demyelinating diseases of CNS. PLoS One 11(11), e0166277 (2016).

    5. Kong, M., Hou, L., Wang, J., et al. Enhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapy. Chem. Commun. (Camb.) 51(8), 1453-1456 (2015).