A fluorescent neuronal retrograde tracer and nucleic acid dye
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Hydroxystilbamidine (methanesulfonate)

Item No. 26858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-[4-(aminoiminomethyl)phenyl]ethenyl]-3-hydroxy-benzenecarboximidamide, dimethanesulfonate
CAS Number
223769-64-0
Molecular Formula
C16H16N4O • 2CH3SO3H
Formula Weight
472.5
Emission
620 nm for tissue sections; 600 and 450 nm for DNA and RNA purposes, respectively
Excitation
323 nm for tissue sections; 360 nm for DNA and RNA purposes
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
OC1=C(/C=C/C2=CC=C(C(N)=N)C=C2)C=CC(C(N)=N)=C1.O=S(C)(O)=O.O=S(C)(O)=O
InChi Code
InChI=1S/C16H16N4O.2CH4O3S/c17-15(18)12-5-2-10(3-6-12)1-4-11-7-8-13(16(19)20)9-14(11)21;2*1-5(2,3)4/h1-9,21H,(H3,17,18)(H3,19,20);2*1H3,(H,2,3,4)/b4-1+;;
InChi Key
YGNSQKCULHSJDC-HFPMQDOPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $116

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    10 mg

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    Product Description

    Hydroxystilbamidine is a fluorescent neuronal retrograde tracer that labels the neuronal cell body as well as proximal dendrites.1,2 Hydroxystilbamidine, when visualized in tissue sections, displays excitation/emission maxima of 323/620 nm, respectively. It is also a nucleic acid dye that can be used to label DNA and RNA in fixed or unfixed dead cells.3 It displays an excitation maximum of 360 nm and emission maxima of 450 and 600 nm when bound to DNA but only emits at 450 nm when bound to RNA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Akhavan, M., Hoang, T.X., and Havton, L.A. Improved detection of fluorogold-labeled neurons in long-term studies. J. Neurosci. Methods 152(1-2), 156-162 (2006).

    2. Li, C., Marshall, C.T., Lu, C., et al. The dynamic distribution of fluoro-gold and its interrelation with neural nitric oxide synthase following intracerebroventricular injection into rat brain. Biotech. Histochem. 81(1), 41-50 (2006).

    3. Festy, B., and Daune, M. Hydroxystilbamidine. A nonintercalating drug as a probe of nucleic acid conformation. Biochemistry 12(24), 4827-4834 (1973).