A flavonoid with diverse biological activities
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Myricetrin

Item No. 26902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
CAS Number
17912-87-7
Synonyms
  • Myricitrin
  • Myricitrine
  • Myricitroside
  • NSC 19803
Molecular Formula
C21H20O12
Formula Weight
464.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 2 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
λmax
259, 354 nm
SMILES
OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC(O)=C(O)C(O)=C3)O4)=O)C4=C1
InChi Code
InChI=1S/C21H20O12/c1-6-14(26)17(29)18(30)21(31-6)33-20-16(28)13-9(23)4-8(22)5-12(13)32-19(20)7-2-10(24)15(27)11(25)3-7/h2-6,14,17-18,21-27,29-30H,1H3/t6-,14-,17+,18+,21-/m0/s1
InChi Key
DCYOADKBABEMIQ-OWMUPTOHSA-N
Origin
Plant/Myrica rubra bark
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Product Description

    Myricetrin is a flavonoid that has been found in C. menyharthii leaf extracts and has diverse biological activities.1,2 It is active against B. subtilis, E. coli, K. pneumoniae, S. aureus, and C. albicans (MIC = 0.25 mg/ml for all).1 Myricetrin inhibits acetylcholinesterase (AChE) and α-glucosidase in vitro (IC50s = 65 and 79 μg/ml, respectively). It inhibits LPS-induced production of TNF-α and enhances LPS-induced RANTES production in RAW 264.7 cells when used at concentrations of 0.2 and 1 mM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aderogba, M.A., Ndhlala, A.R., Rengasamy, K.R., et al. Antimicrobial and selected in vitro enzyme inhibitory effects of leaf extracts, flavonols and indole alkaloids isolated from Croton menyharthii. Molecules 18(10), 12633-12644 (2013).

    2. Shimosaki, S., Tsurunaga, Y., Itamura, H., et al. Anti-allergic effect of the flavonoid myricitrin from Myrica rubra leaf extracts in vitro and in vivo. Nat. Prod. Res. 25(4), 374-380 (2011).