An antiviral agent
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(±)-BAY 41-4109

Item No. 26907

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid, methyl ester
CAS Number
298708-79-9
Molecular Formula
C18H13ClF3N3O2
Formula Weight
395.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:5): 0.16 mg/mlEthanol: 0.3 mg/ml
λmax
210, 277 nm
SMILES
FC1=CC(F)=C(C2=NC(C)=C(C(OC)=O)C(C3=CC=C(F)C=C3Cl)N2)N=C1
InChi Code
InChI=1S/C18H13ClF3N3O2/c1-8-14(18(26)27-2)15(11-4-3-9(20)5-12(11)19)25-17(24-8)16-13(22)6-10(21)7-23-16/h3-7,15H,1-2H3,(H,24,25)
InChi Key
FVNJBPMQWSIGJK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    (±)-BAY 41-4109 is a heteroaryldihydropyrimidine with antiviral activity.1 It inhibits hepatitis B virus (HBV) replication in HepG2.2.15 cells (IC50 = 202 nM) without affecting cell growth. (±)-BAY 41-4109 (25 mg/kg) reduces viral replication and viral load in a humanized mouse model of HBV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Brezillon, N., Brunelle, M.-N., Massinet, H., et al. Antiviral activity of Bay 41-4109 on hepatitis B virus in humanized Alb-uPA/SCID mice. PLoS One 6(12), e25096 (2011).