An agonist of S. hermonthica ShHTL7
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Sphynolactone-7

Item No. 26922

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4-butoxyphenyl)sulfonyl]-1-piperazinecarboxylic acid, 2,5-dihydro-4-methyl-5-oxo-2-furanyl ester
CAS Number
2305752-57-0
Synonyms
  • SPL7
Molecular Formula
C20H26N2O7S
Formula Weight
438.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble (warmed)
SMILES
CCCCOC1=CC=C(S(N2CCN(C(OC3C=C(C)C(O3)=O)=O)CC2)(=O)=O)C=C1
InChi Code
InChI=1S/C20H26N2O7S/c1-3-4-13-27-16-5-7-17(8-6-16)30(25,26)22-11-9-21(10-12-22)20(24)29-18-14-15(2)19(23)28-18/h5-8,14,18H,3-4,9-13H2,1-2H3
InChi Key
GGAPQPVAXJSNFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $174

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    10 mg

    $649

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    Product Description

    Sphynolactone-7 (SPL7) is an agonist of Striga hyposensitive to light receptor 7 (ShHTL7), which is found in the parasitic plant S. hermonthica.1 It selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively). SPL7 induces S. hermonthica seed germination in the absence of a host, which is fatal to this obligate parasite, with a minimum effective concentration of 10 fM. It induces suicidal germination of S. hermonthica seeds and decreases the number of plants emerging from the soil, as well as reduces S. hermonthica-induced senescence in maize plants when pre-applied to the soil of co-cultivated maize plants and S. hermonthica seeds at a concentration of 10 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uraguchi, D., Kuwata, K., Hijikata, Y., et al. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science 362(6420), 1301-1305 (2018).