A turn-on fluorescent probe for carbon monoxide
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LysoFP-NO2

Item No. 27024

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(4-morpholinyl)ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione
CAS Number
69408-75-9
Molecular Formula
C18H17N3O5
Formula Weight
355.3
Purity
≥98%
Emission
528 nm
Excitation
440 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
λmax
219, 275, 332 nm
SMILES
O=C1C2=C3C(C(N1CCN4CCOCC4)=O)=CC=CC3=CC([N+]([O-])=O)=C2
InChi Code
InChI=1S/C18H17N3O5/c22-17-14-3-1-2-12-10-13(21(24)25)11-15(16(12)14)18(23)20(17)5-4-19-6-8-26-9-7-19/h1-3,10-11H,4-9H2
InChi Key
MQBIIGAYEJQXCC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $108

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    10 mg

    $196

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    25 mg

    $437

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    Product Description

    LysoFP-NO2 is a turn-on fluorescent probe for carbon monoxide (CO) that localizes to the lysosome.1 In the presence of lysosomal CO, lysoFP-NO2 is transformed into lysoFP-NH2, which is highly fluorescent. LysoFP-NO2 is selective for CO over various reactive nitrogen, oxygen, and sulfur species. It displays excitation/emission maxima of 440/528 nm, respectively, and is not cytotoxic to HepG2 cells for up to five hours when used at a concentration of 30 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dhara, K., Lohar, S., Patra, A., et al. A new lysosome-targetable turn-on fluorogenic probe for carbon monoxide imaging in living cells. Anal. Chem. 90(4), 2933-2938 (2018).