A triterpene saponin with diverse biological activities
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Hederagenin

Item No. 27030

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4α)-3β,23-dihydroxy-olean-12-en-28-oic acid
CAS Number
465-99-6
Synonyms
  • Astrantiagenin E
  • Caulosapogenin
  • Hederagenic Acid
  • NSC 24954
Molecular Formula
C30H48O4
Formula Weight
472.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
O[C@H]1CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@]5(C(O)=O)CC[C@@]4(C)[C@]3(C)CC[C@@]2([H])[C@]1(C)CO
InChi Code
InChI=1S/C30H48O4/c1-25(2)13-15-30(24(33)34)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23(32)27(4,18-31)21(26)9-12-29(22,28)6/h7,20-23,31-32H,8-18H2,1-6H3,(H,33,34)/t20-,21+,22+,23-,26-,27-,28+,29+,30-/m0/s1
InChi Key
PGOYMURMZNDHNS-MYPRUECHSA-N
Origin
Plant/Lonicera fulvotomentosa
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $160

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    100 mg

    $304

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    250 mg

    $719

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    500 mg

    $1,038

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    Product Description

    Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities.1,2,3,4,5 It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells.2 In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis.3 Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity.4 It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson's disease induced by MPTP.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jayasinghe, L., Shimada, H., Hara, N., et al. Hederagenin glycosides from Pometia eximia. Phytochemistry 40(3), 891-897 (1995).

    2. Kim, E.H., Baek, S., Shin, D., et al. Hederagenin induces apoptosis in cisplatin-resistant head and neck cancer cells by inhibiting the Nrf2-ARE antioxidant pathway. Oxid. Med. Cell. Longev. 5498908 (2017).

    3. Lu, S.-H., Guan, J.-H., Huang, Y.-L., et al. Experimental study of antiatherosclerosis effects with hederagenin in rats. Evid. Based Complement. Alternat. Med. 456354 (2015).

    4. Kim, G.-J., Song, D.H., Yoo, H.S., et al. Hederagenin supplementation alleviates the pro-inflammatory and apoptotic response to alcohol in rats. Nutrients 9(1), E41 (2017).

    5. Wu, A.-G., Zeng, W., Wong, V.K.-W., et al. Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice. Pharmacol. Res. 115, 25-44 (2017).