A positive allosteric modulator of mGluR4
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Lu AF21934

Item No. 27045

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-(3,4-dichlorophenyl)-1S,2R-cyclohexanedicarboxamide
CAS Number
1445605-23-1
Molecular Formula
C14H16Cl2N2O2
Formula Weight
315.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
211, 252 nm
SMILES
O=C(NC1=CC(Cl)=C(Cl)C=C1)[C@@H]2[C@H](C(N)=O)CCCC2
InChi Code
InChI=1S/C14H16Cl2N2O2/c15-11-6-5-8(7-12(11)16)18-14(20)10-4-2-1-3-9(10)13(17)19/h5-7,9-10H,1-4H2,(H2,17,19)(H,18,20)/t9-,10+/m1/s1
InChi Key
AVKZWCJNDWOBAM-ZJUUUORDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $49

    Add

    5 mg

    $130

    Add

    10 mg

    $236

    Add

    25 mg

    $527

    Add
    Product Description

    Lu AF21934 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4; EC50 = 500 nM for the human receptor in a FLIPR assay).1 It is selective for mGluR4 over mGluR6 (EC50 = 7 μM) and a panel of 73 CNS ion channels, G protein-coupled receptors (GPCRs), and enzymes at 10 μM. Lu AF21934 (12 mg/kg) reduces marble burying behavior and stress-induced hyperthermia in mice, indicating anxiolytic-like activity, but also reduces locomotor activity. It inhibits MK-801- and amphetamine-induced hyperactivity in mice and prevents MK-801-induced decreases in social interaction in rats.2 Lu AF21934 (0.5 and 2.5 mg/kg) also reduces harmaline-induced hyperactivity, but not tremor, in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sławińska, A., Wierońska, J.M., Stachowicz, K., et al. Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu4 receptor. Neuropharmacology 66, 225-235 (2013).

    2. Sławińska, A., Wierońska, J.M., Stachowicz, K., et al. The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents. Br. J. Pharmacol. 169(8), 1824-1839 (2013).

    3. Ossowska, K., Wardas, J., Berghauzen-Maciejewska, K., et al. Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. Neuropharmacology 83, 28-35 (2014).