An isoflavone glycoside
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Ononin

Item No. 27046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-(β-D-glucopyranosyloxy)-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
486-62-4
Synonyms
  • Formononetin 7-O-β-D-Glucopyranoside
  • Formononetin Glucoside
  • Formononetin 7-O-Glucoside
Molecular Formula
C22H22O9
Formula Weight
430.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: Partially solublePBS (pH 7.2): 0.25 mg/ml
λmax
233, 262 nm
SMILES
O=C1C2=CC=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2OC=C1C4=CC=C(OC)C=C4
InChi Code
InChI=1S/C22H22O9/c1-28-12-4-2-11(3-5-12)15-10-29-16-8-13(6-7-14(16)18(15)24)30-22-21(27)20(26)19(25)17(9-23)31-22/h2-8,10,17,19-23,25-27H,9H2,1H3/t17-,19-,20+,21-,22-/m1/s1
InChi Key
MGJLSBDCWOSMHL-MIUGBVLSSA-N
Origin
Plant/Astragalus membranaceus (Fisch.) Bunge
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $134

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    10 mg

    $213

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    25 mg

    $432

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    50 mg

    $662

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    Cayman Chemical
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    Product Description

    Ononin is a glycoside isoflavone that has been found in soybeans and A. mongholicus and has anti-inflammatory and neuroprotective activities.1,2,3 Ononin (5 µM) inhibits LPS-induced production of nitrite, prostaglandin E2 (PGE2; Item No. 14010), and the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α by RAW 264.7 macrophages.3 It also inhibits glutamate-induced toxicity in rat adrenal PC12 cells when used at a concentration of 0.025 µg/ml.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, T., Liu, Y., Li, X., et al. Isoflavones from green vegetable soya beans and their antimicrobial and antioxidant activities. J. Sci. Food Agric. 98(5), 2043-2047 (2018).

    2. Yu, D., Duan, Y., Bao, Y., et al. Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by L-glutamate. J. Ethnopharmacol. 98(1-2), 89-94 (2005).

    3. Dong, L., Yin, L., Zhang, Y., et al. Anti-inflammatory effects of ononin on lipopolysaccharide-stimulated RAW 264.7 cells. Mol. Immunol. 83, 46-51 (2017).