An anticoccidial agent
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Diclazuril

Item No. 27047

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile
CAS Number
101831-37-2
Synonyms
  • R-64433
Molecular Formula
C17H9Cl3N4O2
Formula Weight
407.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLDMSO:PBS (pH 7.2) (1:5): 0.16mg/mL
λmax
222, 245, 279 nm
SMILES
ClC1=CC=C(C(C#N)C2=C(Cl)C=C(N3C(NC(C=N3)=O)=O)C=C2Cl)C=C1
InChi Code
InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)
InChi Key
ZSZFUDFOPOMEET-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Diclazuril is an anticoccidial agent.1,2 It decreases the number of oocysts per gram of feces in a broiler chicken model of E. tenella coccidiosis infection.1 Diclazuril (1 and 2 mg/kg) decreases fecal oocyst shedding in goat kid models of E. arloingi, E. ninakohlyakimovae, and E. christenseni infection.2 It also inhibits B. besnoiti tachyzoite proliferation in MARC-145 cells (IC99 = 29.9 μM).3 Formulations containing diclazuril have been used in the prevention and treatment of coccidiosis in livestock.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, D., Zhou, L., Li, W., et al. Anticoccidial effect of Piper sarmentosum extracts in experimental coccidiosis in broiler chickens. Trop. Anim. Health Prod. 48(5), 1071-1078 (2016).

    2. Ruiz, A., Guedes, A.C., Muñoz, M.C., et al. Control strategies using diclazuril against coccidiosis in goat kids. Parasitol Res. 110(6), 2131-2136 (2012).

    3. Jiménez-Meléndez, A., Rico-San Román, L., Hemphill, A., et al. Repurposing of commercially available anti-coccidials identifies diclazuril and decoquinate as potential therapeutic candidates against Besnoitia besnoiti infection. Vet. Parasitol. 261, 77-85 (2018).