An inhibitor of glucose transport
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Fasentin

Item No. 27050

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-butanamide
CAS Number
392721-37-8
Molecular Formula
C11H9ClF3NO2
Formula Weight
279.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
ClC1=C(C(F)(F)F)C=C(NC(CC(C)=O)=O)C=C1
InChi Code
InChI=1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
InChi Key
GNYIJZMBLZXJEJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $110

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    10 mg

    $153

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    25 mg

    $288

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    Cayman Chemical
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    Product Description

    Fasentin is an inhibitor of glucose transport.1 It partially inhibits glucose uptake in U937 and DU145 cells when used at concentrations ranging from 15 to 80 µM. Fasentin sensitizes PPC-1 prostate cancer and U937 leukemia cells, but not DU145 prostate cancer cells, to cell death induced by the Fas receptor activator CH-11 activating anti-Fas antibody (FAS). It also increases the expression of AspSyn and PCK2, genes associated with glucose deprivation, in PPC-1 cells and halts the cell cycle at the G0/G1 phase in U937 cells when used at concentrations of 50 and 40 µM, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wood, T.E., Dalili, S., Simpson, C.D., et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol. Cancer Ther. 7(11), 3546-3555 (2008).