A caspase-8 inhibitor
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Ac-IETD-CHO (trifluoroacetate salt)

Item No. 27100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-L-threoninamide, trifluoroacetate salt
Synonyms
  • Ac-Ile-Glu-Thr-Asp-CHO
  • Caspase-8 Inhibitor
Molecular Formula
C21H34N4O10 • XCF3COOH
Formula Weight
502.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
C[C@@H](O)[C@@H](C(N[C@@H](CC(O)=O)C=O)=O)NC([C@@H](NC([C@H]([C@@H](C)CC)NC(C)=O)=O)CCC(O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C21H34N4O10.C2HF3O2/c1-5-10(2)17(22-12(4)28)20(34)24-14(6-7-15(29)30)19(33)25-18(11(3)27)21(35)23-13(9-26)8-16(31)32;3-2(4,5)1(6)7/h9-11,13-14,17-18,27H,5-8H2,1-4H3,(H,22,28)(H,23,35)(H,24,34)(H,25,33)(H,29,30)(H,31,32);(H,6,7)/t10-,11+,13-,14-,17-,18-;/m0./s1
InChi Key
DRJDTCBFGGHFNF-OTQRSQIRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $90

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    5 mg

    $306

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    Product Description

    Ac-IETD-CHO is an inhibitor of caspase-8 (IC50 = 5 nM).1 It inhibits fluticasone propionate-induced increases in apoptosis in peripheral blood T-cells isolated from patients with asthma when used at a concentration 60 μM.2 Ac-IETD-CHO (10 mg/kg) inhibits increases in hepatic caspase-3 activity, DNA fragmentation, cytosolic cytochrome c levels, and proteolytic processing of caspase-3, -8, and -9 proenzymes in a mouse model of Fas-induced apoptosis and liver failure.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, G.K., Barrett, D.G., Blackburn, K.J., et al. Expression, preparation, and high-throughput screening of caspase-8: Discovery of redox-based and steroid diacid inhibition. Arch. Biochem. Biophys. 399(2), 195-205 (2002).

    2. Pace, E., Gagliardo, R., Melis, M., et al. Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma. J. Allergy. Clin. Immunol. 114(5), 1216-1223 (2004).

    3. Bajt, M.L., Lawson, J.A., Vonderfecht, S.L., et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: Evidence for a postmitochondrial processing of caspase-8. Toxicol. Sci. 58(1), 109-117 (2000).