An inhibitor of caspase-3
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Ac-DMQD-CHO (trifluoroacetate salt)

Item No. 27103

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-α-aspartyl-L-methionyl-N1-[(1S)-2-carboxy-1-formylethyl]-L-glutamamide, trifluoroacetate salt
Synonyms
  • Ac-Asp-Met-Gln-Asp-CHO
  • Caspase-3 Inhibitor
Molecular Formula
C20H31N5O10S • XCF3COOH
Formula Weight
533.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC(CC[C@H](NC([C@H](CCSC)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)C(N[C@H](C=O)CC(O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C20H31N5O10S.C2HF3O2/c1-10(27)22-14(8-17(31)32)20(35)25-13(5-6-36-2)19(34)24-12(3-4-15(21)28)18(33)23-11(9-26)7-16(29)30;3-2(4,5)1(6)7/h9,11-14H,3-8H2,1-2H3,(H2,21,28)(H,22,27)(H,23,33)(H,24,34)(H,25,35)(H,29,30)(H,31,32);(H,6,7)/t11-,12-,13-,14-;/m0./s1
InChi Key
NLPCSCWRVYMUIO-ZMNOQRQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $378

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    Product Description

    Ac-DMQD-CHO is a peptide inhibitor of caspase-3 (IC50 = 39 nM).1 It is selective for caspase-3 over caspase-1 and caspase-8 (IC50s = 148 and 1,100 nM, respectively). Ac-DMQD-CHO inhibits apoptosis induced by camptothecin (Item No. 11694) in immortalized human T/C 28a4 chondrocytes and primary human chondrocytes. In vivo, Ac-DMQD-CHO (1 mg/kg, i.v.) reduces the number of apoptotic cells, cavitation, and demyelination in a rat model of traumatic injury to the spinal cord.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nuttall, M.E., Nadeau, D.P., Fisher, P.W., et al. Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro. J. Orthop. Res. 18(3), 356-363 (2000).

    2. Akdemir, O., Berksoy, I., Karaoğlan, A., et al. Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury. J. Clin. Neurosci. 15(6), 672-678 (2008).