A peptide fragment of ACTH
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ACTH (1-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 27105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine, trifluoroacetate salt
Synonyms
  • Adrenocorticotropic Hormone (1-10)
  • Corticotropin (1-10)
Molecular Formula
C59H78N16O16S • XCF3COOH
Formula Weight
1299.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)CCSC)=O)=O)CC5=CC=C(O)C=C5)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C59H78N16O16S.C2HF3O2/c1-92-21-19-42(70-58(91)47(30-77)75-56(89)43(71-50(83)38(60)29-76)23-33-13-15-36(78)16-14-33)54(87)69-41(17-18-48(79)80)53(86)74-46(25-35-27-63-31-67-35)57(90)72-44(22-32-8-3-2-4-9-32)55(88)68-40(12-7-20-64-59(61)62)52(85)73-45(51(84)66-28-49(81)82)24-34-26-65-39-11-6-5-10-37(34)39;3-2(4,5)1(6)7/h2-6,8-11,13-16,26-27,31,38,40-47,65,76-78H,7,12,17-25,28-30,60H2,1H3,(H,63,67)(H,66,84)(H,68,88)(H,69,87)(H,70,91)(H,71,83)(H,72,90)(H,73,85)(H,74,86)(H,75,89)(H,79,80)(H,81,82)(H4,61,62,64);(H,6,7)/t38-,40-,41-,42-,43-,44-,45-,46-,47-;/m0./s1
InChi Key
YWRKPAFZGKNGFO-JXBCAYJYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    Adrenocorticotropic hormone (ACTH) (1-10) is an N-terminal peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.1,2 The amino acid sequence of ACTH (1-10) is common to ACTH and α-melanocyte stimulating hormone.3 ACTH (1-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 2.6 and 200 nM, respectively, for the recombinant human receptors) and increases adenylate cyclase activity in HEK293 cells expressing human recombinant MC1R (EC50 = 25 nM).3,4 It inhibits extinction of the conditioned avoidance response rats in shuttle-box and pole-jumping tests when administered at doses of 10 and greater than 20 μg, respectively.1,5 Intracerebroventricular injection of ACTH (1-10) reduces the incidence and severity of cold-restraint stress-induced gastric lesions in rats.6

    WARNING This product is not for human or veterinary use.