An endogenous peptide fragment of ACTH
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ACTH (4-10) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 27106

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-glycine, trifluoroacetate salt
Synonyms
  • Adrenocorticotropic Hormone (4-10)
  • Corticotropin (4-10)
Molecular Formula
C44H59N13O10S • XCF3COOH
Formula Weight
962.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)CC3=CC=CC=C3)=O)CC4=CN=CN4)=O)=O)CCSC
InChi Code
InChI=1S/C44H59N13O10S.C2HF3O2/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30;3-2(4,5)1(6)7/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49);(H,6,7)/t29-,31-,32-,33-,34-,35-;/m0./s1
InChi Key
ICCLJCOVWYXLTE-CZPFDPCBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $132

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    Product Description

    Adrenocorticotropic hormone (ACTH) (4-10) is an endogenous peptide fragment of ACTH, a peptide hormone produced by the anterior pituitary gland that is involved in the biological stress response.1 ACTH (4-10) is found in the septal nuclei, the third ventricle, and ventral horn motor neurons.1,2 The amino acid sequence of ACTH (4-10) is common to ACTH and the α- and β-melanocyte stimulating hormones.3 ACTH (4-10) is an agonist of melanocortin receptor 3 (MC3R) and MC4R (EC50s = 23 and 330 nM for the human recombinant receptors, respectively). It increases mean arterial pressure (ED50 = 287 nmol/kg) and heart rate (ED50 = 313 nmol/kg) in rats.4 It also improves aortic and coronary blood flow and left ventricular developed pressure following cardiac ischemia and reperfusion when administered at a dose of 200 µg/kg in rats, as well as reduces the infarct size and decreases caspase-3 activity.5 ACTH (4-10) (10 µg per animal) accelerates motor function improvements in a rat model of sciatic nerve crush.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    2. Strand, F.L. David and Goliath - the slingshot that started the neuropeptide revolution. Eur. J. Pharmacol. 405(1-3), 3-12 (2000).

    3. Miwa, H., Gantz, I., Konda, Y., et al. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J. Pharmacol. Exp. Ther. 273(1), 367-372 (1995).

    4. Van Bergen, P., Janssen, P.M.L., Hoogerhout, P., et al. Cardiovascular effects of γ-MSH/ACTH-like peptides: Structure-activity relationship. Eur. J. Pharmacol. 294(2-3), 795-803 (1995).

    5. Juhasz, B., Der, P., Szodoray, P., et al. Adrenocorticotrope hormone fragment (4-10) attenuates the ischemia/reperfusion-induced cardiac injury in isolated rat hearts. Antioxid. Redox Signal. 9(11), 1851-1861 (2007).