A 28-residue amyloid-β protein fragment
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Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)

Item No. 27107

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysine, trifluoroacetate salt
Synonyms
  • Aβ (1-28)
  • Aβ28
Molecular Formula
C145H209N41O46 • XCF3COOH
Formula Weight
3262.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 0.15 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(NCC(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)C)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CN=CN4)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)CC(O)=O)=O)CC6=CN=CN6)=O)=O)CC7=CC=CC=C7)=O)=O)C)=O)CC(O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C145H209N41O46.C2HF3O2/c1-71(2)49-93(138(225)186-118(74(7)8)142(229)181-97(52-79-29-18-13-19-30-79)132(219)175-95(50-77-25-14-11-15-26-77)129(216)163-76(10)120(207)167-90(40-44-111(196)197)127(214)179-103(60-115(204)205)139(226)184-116(72(3)4)141(228)158-65-109(193)165-105(67-188)140(227)178-101(58-107(150)191)136(223)172-92(144(231)232)32-21-23-47-147)173-123(210)86(31-20-22-46-146)168-125(212)88(38-42-106(149)190)170-133(220)98(54-81-61-153-68-159-81)177-135(222)100(56-83-63-155-70-161-83)182-143(230)117(73(5)6)185-128(215)91(41-45-112(198)199)171-130(217)94(53-80-34-36-84(189)37-35-80)164-108(192)64-157-122(209)104(66-187)183-137(224)102(59-114(202)203)180-134(221)99(55-82-62-154-69-160-82)176-124(211)87(33-24-48-156-145(151)152)169-131(218)96(51-78-27-16-12-17-28-78)174-126(213)89(39-43-110(194)195)166-119(206)75(9)162-121(208)85(148)57-113(200)201;3-2(4,5)1(6)7/h11-19,25-30,34-37,61-63,68-76,85-105,116-118,187-189H,20-24,31-33,38-60,64-67,146-148H2,1-10H3,(H2,149,190)(H2,150,191)(H,153,159)(H,154,160)(H,155,161)(H,157,209)(H,158,228)(H,162,208)(H,163,216)(H,164,192)(H,165,193)(H,166,206)(H,167,207)(H,168,212)(H,169,218)(H,170,220)(H,171,217)(H,172,223)(H,173,210)(H,174,213)(H,175,219)(H,176,211)(H,177,222)(H,178,227)(H,179,214)(H,180,221)(H,181,229)(H,182,230)(H,183,224)(H,184,226)(H,185,215)(H,186,225)(H,194,195)(H,196,197)(H,198,199)(H,200,201)(H,202,203)(H,204,205)(H,231,232)(H4,151,152,156);(H,6,7)/t75-,76-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,116-,117-,118-;/m0./s1
InChi Key
XQCAKHZIUQZVJU-NDUKRNHYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    2.5 mg

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    5 mg

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    Product Description

    Amyloid-β (1-28) (Aβ28) is a synthetic peptide that lacks 14 C-terminal amino acids and is more soluble than Aβ42 (Item No. 20574).1 Aβ28 forms fibrils and plaques in vitro that are similar to those formed by Aβ42 and induces learning deficits in a passive avoidance task in rats.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Syme, C.D., Nadal, R.C., Rigby, S.E., et al. Copper binding to the amyloid-beta (Aβ) peptide associated with Alzheimer’s disease. Folding, coordination geometry, pH dependence, stoichiometry, and affinity of Aβ(1-28): Insights from a range of complementary spectroscopic techniques. The Journal of Biological Chemisty 279(18), 18169-18177 (2004).

    2. Kirschner, D.A., Inouye, H., Duffy, L.K., et al. Synthetic peptide homologous to β protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 84(19), 6953-6957 (1987).

    3. Burdick, D., Soreghan, B., Kwon, M., et al. Assembly and aggregation properties of synthetic Alzheimer’s A4/β amyloid peptide analogs. The Journal of Biological Chemisty 267(1), 546-554 (1992).

    4. Alvarez, X.A., Miguel-Hidalgo, J.J., Fernández-Novoa, L., et al. Intrahippocampal injections of the beta-amyloid 1-28 fragment induces behavioral deficits in rats. Methods Find. Exp. Clin. Pharmacol. 19(7), 471-479 (1997).