A truncated form of rat adrenomedullin
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Adrenomedullin (11-50) (rat) (trifluoroacetate salt)

Item No. 27124

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11-50-adrenomedullin (rat), trifluoroacetate salt
Synonyms
  • ADM
  • AM
Molecular Formula
C194H304N58O59S4 • XCF3COOH
Formula Weight
4521.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H](NC(CNC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CO)NC([C@@]([C@H](CC)C)([H])NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](N3)CSSC[C@H](NC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CO)N[H])=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)C)=O)CC5=CN=CN5)=O)=O)=O)CC6=CC=C(O)C=C6)=O)=O)CC7=CC=CC=C7)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CC(O)=O)=O)=O)CCSC)=O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC8=CC=C(O)C=C8)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C194H304N58O59S4.C2HF3O2/c1-15-96(5)151(247-173(292)121(58-62-142(203)264)230-176(295)129(80-108-85-210-94-217-108)234-158(277)98(7)218-174(293)125(75-95(3)4)235-164(283)112(39-23-27-65-195)223-169(288)119(56-60-140(201)262)228-171(290)123(64-74-313-14)233-189(308)155(102(11)257)250-182(301)136-93-315-314-92-135(222-146(268)88-216-185(304)153(100(9)255)248-159(278)111(199)90-253)181(300)227-116(43-31-69-211-193(206)207)167(286)236-126(77-104-35-19-17-20-36-104)161(280)215-89-147(269)245-154(101(10)256)188(307)244-136)186(305)241-127(79-107-49-53-110(260)54-50-107)175(294)229-120(57-61-141(202)263)170(289)237-128(78-105-37-21-18-22-38-105)180(299)249-156(103(12)258)190(309)242-133(84-150(274)275)179(298)225-114(41-25-29-67-197)166(285)240-132(83-149(272)273)178(297)224-113(40-24-28-66-196)165(284)239-131(82-148(270)271)162(281)214-86-144(266)220-122(63-73-312-13)163(282)219-99(8)191(310)251-71-33-45-137(251)183(302)231-117(44-32-70-212-194(208)209)168(287)238-130(81-143(204)265)177(296)226-115(42-26-30-68-198)172(291)246-152(97(6)16-2)187(306)243-134(91-254)192(311)252-72-34-46-138(252)184(303)232-118(55-59-139(200)261)160(279)213-87-145(267)221-124(157(205)276)76-106-47-51-109(259)52-48-106;3-2(4,5)1(6)7/h17-22,35-38,47-54,85,94-103,111-138,151-156,253-260H,15-16,23-34,39-46,55-84,86-93,195-199H2,1-14H3,(H2,200,261)(H2,201,262)(H2,202,263)(H2,203,264)(H2,204,265)(H2,205,276)(H,210,217)(H,213,279)(H,214,281)(H,215,280)(H,216,304)(H,218,293)(H,219,282)(H,220,266)(H,221,267)(H,222,268)(H,223,288)(H,224,297)(H,225,298)(H,226,296)(H,227,300)(H,228,290)(H,229,294)(H,230,295)(H,231,302)(H,232,303)(H,233,308)(H,234,277)(H,235,283)(H,236,286)(H,237,289)(H,238,287)(H,239,284)(H,240,285)(H,241,305)(H,242,309)(H,243,306)(H,244,307)(H,245,269)(H,246,291)(H,247,292)(H,248,278)(H,249,299)(H,250,301)(H,270,271)(H,272,273)(H,274,275)(H4,206,207,211)(H4,208,209,212);(H,6,7)/t96-,97-,98-,99-,100+,101+,102+,103+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,
InChi Key
AVDFBVFYJOGHAH-ODTRONMYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $281

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    1 mg

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    Product Description

    Adrenomedullin (11-50) is a truncated form of rat adrenomedullin.1,2 Intravenous administration of adrenomedullin (11-50) (3-10 μg/animal) decreases mean systemic arterial pressure in rats in a dose-dependent manner without affecting cardiac output.1 Cerebroventricular injection of adrenomedullin (11-50) (88 pmol) reduces water intake in response to angiotensin II (Item No. 17150), overnight water deprivation, and hyperosmotic challenge in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lin, B., Gao, Y., Chang, J.K., et al. An adrenomedullin fragment retains the systemic vasodepressor activity of rat adrenomedullin. Eur. J. Pharmacol. 260(1), 1-4 (1994).

    2. Murphy, T.C., and Samson, W.K. The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat. Endocrinology 136(6), 2459-2469 (1995).