A peptide agonist of PAR2
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PAR2 (1-6) (mouse, rat)

Item No. 27125

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucine
CAS Number
164081-25-8
Synonyms
  • SLIGRL
Molecular Formula
C29H55N9O8
Formula Weight
657.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H]N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@]([C@H](CC)C)([H])C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C29H55N9O8/c1-7-17(6)23(38-26(43)20(11-15(2)3)36-24(41)18(30)14-39)27(44)34-13-22(40)35-19(9-8-10-33-29(31)32)25(42)37-21(28(45)46)12-16(4)5/h15-21,23,39H,7-14,30H2,1-6H3,(H,34,44)(H,35,40)(H,36,41)(H,37,42)(H,38,43)(H,45,46)(H4,31,32,33)/t17-,18-,19-,20-,21-,23-/m0/s1
InChi Key
CNOKQOBEMGIIAH-JYAZKYGWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    25 mg

    $820

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    Product Description

    PAR2 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse and rat PAR2. It also corresponds to residues 39-44 and 37-42 of the mouse and rat full-length sequences, respectively. PAR2 (1-6) induces relaxation in precontracted rat arteries in a concentration-dependent manner, an effect that can be reduced by the nitric oxide synthase inhibitor L-NNA (Item No. 80220).1 It inhibits keratinocyte growth in the presence and absence of growth factors.2 PAR2 (1-6) inhibits LPS-induced pulmonary neutrophil influx and increases in matrix metalloproteinase-2 (MMP-2) activity in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Villari, A., Giurdanella, G., Bucolo, C., et al. Apixaban enhances vasodilatation mediated by protease-activated receptor 2 in isolated rat arteries. Front. Pharmacol. 8:480, (2017).

    2. Derian, C.K., Eckardt, A.J., and Andrade-Gordon, P. Differential regulation of human keratinocyte growth and differentiation by a novel family of protease-activated receptors. Cell Growth Differ. 8(7), 743-749 (1997).

    3. Moffatt, J.D., Jeffrey, K.L., and Cocks, T.M. Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice. Am. J. Respir. Cell Mol. Biol. 26(6), 680-684 (2002).