A peptide agonist of PAR4
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PAR4 (1-6) (human)

Item No. 27126

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine
CAS Number
225779-44-2
Synonyms
  • GYPGQV
Molecular Formula
C28H41N7O9
Formula Weight
619.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
225, 279 nm
SMILES
[H]NCC(N[C@H](C(N1CCC[C@H]1C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O
InChi Code
InChI=1S/C28H41N7O9/c1-15(2)24(28(43)44)34-25(40)18(9-10-21(30)37)32-23(39)14-31-26(41)20-4-3-11-35(20)27(42)19(33-22(38)13-29)12-16-5-7-17(36)8-6-16/h5-8,15,18-20,24,36H,3-4,9-14,29H2,1-2H3,(H2,30,37)(H,31,41)(H,32,39)(H,33,38)(H,34,40)(H,43,44)/t18-,19-,20-,24-/m0/s1
InChi Key
VTCFYKYDKDAJKZ-XHOYROJHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $168

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    10 mg

    $317

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    Product Description

    PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence.1 It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 µM.2 PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vergnolle, N., Wallace, J.L., Bunnett, N.W., et al. Protease-activated receptors in inflammation, neuronal signaling and pain. Trends Pharmacol. Sci. 22(3), 146-152 (2001).

    2. Xu, W.F., Andersen, H., Whitmore, T.E., et al. Cloning and characterization of human protease-activated receptor 4. Proc. Natl. Acad. Sci. USA 95(12), 6642-6646 (1998).

    3. Andersen, H., Greenberg, D.L., Fujikawa, K., et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc. Natl. Acad. Sci. USA 96(20), 11189-11193 (1999).