A peptide agonist of PAR4
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cardiovascular System
Vasculature
Vasodilation

PAR4 (1-6) amide (human) (trifluoroacetate salt)

Item No. 27127

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valinamide, trifluoroacetate salt
Synonyms
  • GQV-NH2
  • GYPGQV-NH2
  • H-Gly-Tyr-Pro-Gly-Gln-Val-NH2
Molecular Formula
C28H42N8O8 • XCF3COOH
Formula Weight
618.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC(CNC([C@@H]1CCCN1C([C@@H](NC(CN[H])=O)CC2=CC=C(O)C=C2)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C28H42N8O8.C2HF3O2/c1-15(2)24(25(31)41)35-26(42)18(9-10-21(30)38)33-23(40)14-32-27(43)20-4-3-11-36(20)28(44)19(34-22(39)13-29)12-16-5-7-17(37)8-6-16;3-2(4,5)1(6)7/h5-8,15,18-20,24,37H,3-4,9-14,29H2,1-2H3,(H2,30,38)(H2,31,41)(H,32,43)(H,33,40)(H,34,39)(H,35,42);(H,6,7)/t18-,19-,20-,24-;/m0./s1
InChi Key
MMOCFXQKCYLLRG-XESNDDQGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $112

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    1 mg

    $212

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    Product Description

    PAR4 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence.1 It induces contractions in isolated rat gastric longitudinal muscle tissue and endothelium-dependent relaxation of precontracted rat aortic rings (EC50s = 300-400 μM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hollenberg, M.D., Saifeddine, M., Al-Ani, B., et al. Proteinase-activated receptor 4 (PAR4): action of PAR4-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1 and PAR2. Can. J. Physiol. Pharmacol. 77(6), 458-464 (1999).