A peptide agonist of PAR1
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PAR3 (1-6) (human)

Item No. 27129

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-threonyl-L-phenylalanyl-L-arginylglycyl-L-alanyl-L-proline
CAS Number
320347-28-2
Synonyms
  • TFRGAP
Molecular Formula
C29H45N9O8
Formula Weight
647.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H]N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N1CCC[C@H]1C(O)=O)=O)C)=O)=O)=O)CC2=CC=CC=C2)=O
InChi Code
InChI=1S/C29H45N9O8/c1-16(27(44)38-13-7-11-21(38)28(45)46)35-22(40)15-34-24(41)19(10-6-12-33-29(31)32)36-25(42)20(14-18-8-4-3-5-9-18)37-26(43)23(30)17(2)39/h3-5,8-9,16-17,19-21,23,39H,6-7,10-15,30H2,1-2H3,(H,34,41)(H,35,40)(H,36,42)(H,37,43)(H,45,46)(H4,31,32,33)/t16-,17+,19-,20-,21-,23-/m0/s1
InChi Key
LGNVPMUJJJLQHG-WZZXNIEWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $128

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    5 mg

    $553

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    Product Description

    PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaufmann, R., Schulze, B., Krause, G., et al. Proteinase-activated receptors (PARs) - The PAR3 neo-N-terminal peptide TFRGAP interacts with PAR1. Regul. Pept. 125(1-3), 61-66 (2005).