A peptide agonist of PAR1 and PAR2
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PAR3 (1-6) amide (mouse) (trifluoroacetate salt)

Item No. 27130

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-phenylalanyl-L-asparaginylglycylglycyl-L-prolinamide, trifluoroacetate salt
Synonyms
  • H-Ser-Phe-Asn-Gly-Gly-Pro-NH2
  • SFNGGP amide
  • SFNGGP-NH2
  • SFN-NH2
Molecular Formula
C25H36N8O8 • XCF3COOH
Formula Weight
576.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
NC([C@@H]1CCCN1C(CNC(CNC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CO)N[H])=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C25H36N8O8.C2HF3O2/c26-15(13-34)23(39)31-16(9-14-5-2-1-3-6-14)25(41)32-17(10-19(27)35)24(40)30-11-20(36)29-12-21(37)33-8-4-7-18(33)22(28)38;3-2(4,5)1(6)7/h1-3,5-6,15-18,34H,4,7-13,26H2,(H2,27,35)(H2,28,38)(H,29,36)(H,30,40)(H,31,39)(H,32,41);(H,6,7)/t15-,16-,17-,18-;/m0./s1
InChi Key
ZQLFFELRKCHBKB-YPFLJBJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    500 µg

    $112

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    1 mg

    $212

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    Product Description

    PAR3 (1-6) amide is a synthetic hexapeptide that corresponds to amino acid residues 1-6 of the amino terminal tethered ligand sequence of mouse proteinase-activated receptor 3 (PAR3) and residues 38-43 of the full-length sequence. PAR3 (1-6) amide activates PAR1 and PAR2, but not PAR3 or PAR4.1,2 It does not induce thrombin signaling in COS-7 cells expressing PAR3, PAR4, or both receptors at concentrations less than or equal to 500 µM, however, it does activate PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells when used at concentrations of 500 and 1,000 µM.1,2 PAR3 (1-6) increases calcium levels in Kirsten virus-transformed rat kidney (KNRK) cells expressing rat or human PAR2, with a higher potency for rat PAR2.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakanishi-Matsui, M., Zheng, Y.W., Sulciner, D.J., et al. PAR3 is a cofactor for PAR4 activation by thrombin. Nature 404(6778), 609-613 (2000).

    2. Hansen, K.K., Saifeddine, M., and Hollenberg, M.D. Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells. Immunology 112(2), 183-190 (2004).