A peptide agonist of PAR4
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PAR4 (1-6) (mouse) (trifluoroacetate salt)

Item No. 27131

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalanine, trifluoroacetate salt
Synonyms
  • GYPGKF
  • H-Gly-Tyr-Pro-Gly-Lys-Phe-OH
Molecular Formula
C33H45N7O8 • XCF3COOH
Formula Weight
667.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(C(F)(F)F)=O.[H]NCC(N[C@H](C(N1CCC[C@H]1C(NCC(N[C@@H](CCCCN)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O
InChi Code
InChI=1S/C33H45N7O8.C2HF3O2/c34-15-5-4-9-24(30(44)39-26(33(47)48)18-21-7-2-1-3-8-21)37-29(43)20-36-31(45)27-10-6-16-40(27)32(46)25(38-28(42)19-35)17-22-11-13-23(41)14-12-22;3-2(4,5)1(6)7/h1-3,7-8,11-14,24-27,41H,4-6,9-10,15-20,34-35H2,(H,36,45)(H,37,43)(H,38,42)(H,39,44)(H,47,48);(H,6,7)/t24-,25-,26-,27-;/m0./s1
InChi Key
XNLKRKZRBQFCSH-LQHVCSEWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    25 mg

    $820

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    Product Description

    PAR4 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 4 (PAR4; EC50 = 30 μM in Xenopus oocytes expressing human PAR4 receptors) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence.1 It induces calcium release in wild-type and PAR3-/- mouse platelets and in human platelets but has no activity in Xenopus oocytes expressing human PAR1. PAR4 (1-6) also triggers [3H]inositol phosphate release from KOLF cells expressing human PAR4.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kahn, M.L., Zheng, Y.-W., Huang, W., et al. A dual thrombin receptor system for platelet activation. Nature 394(6694), 690-694 (1998).

    2. Faruqi, T.R., Weiss, E.J., Shapiro, M.J., et al. Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. The Journal of Biological Chemisty 275(26), 19728-19734 (2000).