An inhibitor of caspase-3 maturation
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Ac-ESMD-CHO (trifluoroacetate salt)

Item No. 27135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-L-α-glutamyl-L-seryl-N-[(1S)-2-carboxy-1-formylethyl]-L-methioninamide, trifluoroacetate salt
Synonyms
  • Ac-Glu-Ser-Met-Asp-CHO
Molecular Formula
C19H30N4O10S • XCF3COOH
Formula Weight
506.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: 1 mg/ml
SMILES
OC(CC[C@H](NC(C)=O)C(N[C@@H](CO)C(N[C@H](C(N[C@H](C=O)CC(O)=O)=O)CCSC)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C19H30N4O10S.C2HF3O2/c1-10(26)20-12(3-4-15(27)28)18(32)23-14(9-25)19(33)22-13(5-6-34-2)17(31)21-11(8-24)7-16(29)30;3-2(4,5)1(6)7/h8,11-14,25H,3-7,9H2,1-2H3,(H,20,26)(H,21,31)(H,22,33)(H,23,32)(H,27,28)(H,29,30);(H,6,7)/t11-,12-,13-,14-;/m0./s1
InChi Key
HZZVIJGPNMVREQ-ZMNOQRQPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $82

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    Product Description

    Ac-ESMD-CHO is an inhibitor of caspase-3 maturation.1 It inhibits proteolytic cleavage of the 32 kDa caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site, blocking formation of the p17 caspase-3 active subunit.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Han, Z., Hendrickson, E.A., Bremner, T.A., et al. A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. The Journal of Biological Chemisty 272(20), 13432-13436 (1997).