A fluorogenic substrate for caspase-1
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Suc-YVAD-AMC (acetate)

Item No. 27138

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,6S,9S,12S)-12-(4-hydroxybenzyl)-9-isopropyl-6-methyl-3-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-5,8,11,14-tetraoxo-4,7,10,13-tetraazaheptadecanedioic acid, acetate
Synonyms
  • Suc-Tyr-Val-Ala-Asp-AMC
  • Suc-Tyr-Val-Ala-Asp-7-amino-4-methylcoumarin
  • Suc-YVAD-NH-Mec
Molecular Formula
C35H41N5O12 • XC2H4O2
Formula Weight
723.7
Purity
≥95%
Emission
360, 460 nm
Excitation
340, 440 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Formic Acid: 1 mg/ml
SMILES
O=C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC1=CC=C(O)C=C1)NC(CCC(O)=O)=O)=O)=O)N[C@H](C(NC2=CC=C3C(C)=CC(OC3=C2)=O)=O)CC(O)=O.CC(O)=O
InChi Code
InChI=1S/C35H41N5O12.C2H4O2/c1-17(2)31(40-34(50)24(38-27(42)11-12-28(43)44)14-20-5-8-22(41)9-6-20)35(51)36-19(4)32(48)39-25(16-29(45)46)33(49)37-21-7-10-23-18(3)13-30(47)52-26(23)15-21;1-2(3)4/h5-10,13,15,17,19,24-25,31,41H,11-12,14,16H2,1-4H3,(H,36,51)(H,37,49)(H,38,42)(H,39,48)(H,40,50)(H,43,44)(H,45,46);1H3,(H,3,4)/t19-,24-,25-,31-;/m0./s1
InChi Key
RASLRTJPATXDHE-KDAALZGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $69

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    1 mg

    $127

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    Product Description

    Suc-YVAD-AMC is a fluorogenic substrate for caspase-1.1 Upon enzymatic cleavage by caspase-1, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-1 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chakravarthy, B.R., Walker, T., Rasquinha, I., et al. Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells. J. Neurochem. 72(3), 933-942 (1999).