An internal standard for the quantification of sphinganine (d18:0)
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Unlabeled Version(s)
10007945Sphinganine (d18:0)
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Sphinganine-d7 (d18:0)

Item No. 27145

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2S-amino-1,3R-octadecane-16,16,17,17,18,18,18-d7-diol
CAS Number
1246304-35-7
Synonyms
  • Dihydrosphingosine-d7
  • D-erythro-Dihydrosphingosine-d7
  • Dihydro-D-erythro-Sphingosine-d7
  • Sphinganine-d7
  • D-erythro-Sphinganine-d7
Molecular Formula
C18H32D7NO2
Formula Weight
308.6
Purity
≥99% deuterated forms (d1-d7)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 2 mg/mLEthanol: miscible
SMILES
OC[C@H](N)[C@H](O)CCCCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
InChi Code
InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1/i1D3,2D2,3D2
InChi Key
OTKJDMGTUTTYMP-GEZFCKIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    1 mg

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    Product Description

    Sphinganine-d7 (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) (Item No. 10007945) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate (Item No. 62570).1 Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Smith, E.R., and Merrill, A.H., Jr. Differential roles of de novo sphingolipid biosynthesis and turnover in the “Burst” of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. The Journal of Biological Chemisty 270(32), 18749-18758 (1995).

    2. Pruett, S.T., Bushnev, A., Hagedorn, K., et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. J. Lipid Res. 49(8), 1621-1639 (2008).

    3. Shephard, G.S., van der Westhuizen, L., and Sewram, V. Biomarkers of exposure to fumonisin mycotoxins: A review. Food Addit. Contam. 24(10), 1196-1201 (2007).

    4. Yin, J., Miyazaki, K., Shaner, R.L., et al. Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markers. FEBS Lett. 584(9), 1872-1878 (2010).