An irreversible protease inhibitor
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Z-DEVD-CMK (trifluoroacetate salt)

Item No. 27149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-1-(carboxymethyl)-3-chloro-2-oxopropyl]-L-valinamide, trifluoroacetate salt
Synonyms
  • Z-Asp-Glu-Val-Asp-CMK
Molecular Formula
C27H35ClN4O12 • XCF3COOH
Formula Weight
643.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
SMILES
O=C(OCC1=CC=CC=C1)N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(CCl)=O)CC(O)=O)=O)=O)CCC(O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C27H35ClN4O12.C2HF3O2/c1-14(2)23(26(42)30-17(10-21(36)37)19(33)12-28)32-24(40)16(8-9-20(34)35)29-25(41)18(11-22(38)39)31-27(43)44-13-15-6-4-3-5-7-15;3-2(4,5)1(6)7/h3-7,14,16-18,23H,8-13H2,1-2H3,(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,34,35)(H,36,37)(H,38,39);(H,6,7)/t16-,17-,18-,23-;/m0./s1
InChi Key
UBIFJNREVWXBMB-ILOSSIDHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $49

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    1 mg

    $93

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    5 mg

    $213

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    Product Description

    Z-DEVD-CMK is a protease inhibitor.1 It irreversibly inhibits recombinant caspase-3, cathepsin B, cathepsin L, cathepsin V, cathepsin F, and cathepsin S in enzyme assays but has no effect on these cathepsins in Jurkat T cells. Z-DEVD-CMK (3 mg/kg) improves endotoxin-induced myocardial dysfunction and reduces caspase-1, -3, and -8 activation and apoptosis in a rat model of endotoxin-induced myocardial dysfunction and heart apoptosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rozman-Pungercar, J., Kopitar-Jerala, N., Bogyo, M., et al. Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: When reaction mechanism is more important than specificity. Cell Death Differ. 10(8), 881-888 (2003).

    2. Fauvel, H., Marchetti, P., Chopin, C., et al. Differential effects of caspase inhibitors on endotoxin-induced myocardial dysfunction and heart apoptosis. Am. J. Physiol. Heart Circ. Physiol. 280(4), H1608-H1614 (2001).