A peptide fragment of ACTH
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ACTH (1-13) (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)

Item No. 27150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α1-13-corticotropin, trifluoroacetate salt
Synonyms
  • SYSMEHFRWGKPV-OH
Molecular Formula
C75H106N20O19S • XCF3COOH
Formula Weight
1623.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: .2mg/mLDMSO: 10mg/mLEthanol: slightly solublePBS (pH 7.2): 10mg/mL
λmax
278 nm
SMILES
[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)CC2=CNC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4)=O)CC5=CN=CN5)=O)=O)CCSC)=O)=O)CC6=CC=C(O)C=C6)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C75H106N20O19S.C2HF3O2/c1-41(2)62(74(113)114)94-72(111)59-19-12-29-95(59)73(112)53(17-9-10-27-76)85-60(99)37-83-64(103)56(33-44-35-82-49-16-8-7-15-47(44)49)91-65(104)50(18-11-28-81-75(78)79)86-68(107)55(31-42-13-5-4-6-14-42)90-70(109)57(34-45-36-80-40-84-45)92-66(105)51(24-25-61(100)101)87-67(106)52(26-30-115-3)88-71(110)58(39-97)93-69(108)54(89-63(102)48(77)38-96)32-43-20-22-46(98)23-21-43;3-2(4,5)1(6)7/h4-8,13-16,20-23,35-36,40-41,48,50-59,62,82,96-98H,9-12,17-19,24-34,37-39,76-77H2,1-3H3,(H,80,84)(H,83,103)(H,85,99)(H,86,107)(H,87,106)(H,88,110)(H,89,102)(H,90,109)(H,91,104)(H,92,105)(H,93,108)(H,94,111)(H,100,101)(H,113,114)(H4,78,79,81);(H,6,7)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-;/m0./s1
InChi Key
FFIXASBSGNFZNW-JMIITERTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    ACTH (1-13) is a peptide fragment of adrenocorticotropic hormone (ACTH; Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response.1 An acetylated form of ACTH (1-13), α-melanocyte stimulating hormone (α-MSH), is formed in the intermediate lobe of the pituitary gland by cleavage of ACTH (1-39), as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1,2 ACTH (1-13) is an agonist of melanocortin receptor 3 (MC3R) and MC4R, inducing cAMP production in vitro with EC50 values of 0.18 and 19 nM, respectively, which is similar in potency to that of α-MSH.3 It induces differentiation of melanocytes when used at concentrations ranging from 0.001 to 1,000 nM.4 ACTH (1-13) (40 and 400 pmol, i.c.v.) decreases food intake in broiler chicks.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al. Non-corticotropic ACTH peptides modulate nerve development and regeneration. Rev. Neurosci. 4(4), 321-363 (1993).

    2. Catania, A., Airaghi, L., Colombo, G., et al. α-melanocyte-stimulating hormone in normal human physiology and disease states. Trends Endocrinol. Metab. 11(8), 304-308 (2000).

    3. Miwa, H., Gantz, I., Konda, Y., et al. Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptors. J. Pharmacol. Exp. Ther. 273(1), 367-372 (1995).

    4. Hirobe, T., and Hiroyuki, A. ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture. J. Exp. Zool. 286(6), 632-640 (2000).

    5. Saneyasu, T., Honda, K., Kamisoyama, H., et al. Alpha-melanocyte stimulating hormone plays an important role in the regulation of food intake by the central melanocortin system in chicks. Peptides 32(5), 996-1000 (2011).